Irresistible Creamed Chicken and Biscuits Casserole Recipe

Creamed chicken and biscuits casserole represents the ultimate comfort food for anyone seeking a hearty, satisfying meal.

Soft, pillowy biscuits nestle atop a luxurious blend of savory ingredients that promise pure culinary bliss.

Rich, creamy textures mingle with tender protein in a way that instantly soothes and delights the senses.

Home cooks adore how this dish crafts basic pantry staples into something extraordinarily delectable.

Layers of flavor create a harmonious symphony that speaks directly to your hunger and heart.

Family members will eagerly gather around the table, anticipating each warm, indulgent bite.

Prepare to elevate your weeknight dinner with this irresistible crowd-pleasing classic.

Why This Casserole Is a Cold-Weather Favorite

• Effortless Comfort Cooking: Whip up a hearty casserole that transforms simple ingredients into a warm, satisfying meal with minimal kitchen effort and maximum flavor.
• Cheesy Texture Paradise: Enjoy the perfect blend of creamy chicken mixture topped with melted cheddar and golden biscuits, creating a delightful contrast of smooth and crispy textures.
• Quick Family Crowd-Pleaser: Prepare a delicious dinner in under an hour that satisfies both picky eaters and hungry adults, making mealtime stress-free and enjoyable for everyone at the table.

What’s Inside This Creamy Chicken Biscuit Dish

• Cooked Chicken: Tender protein base that provides a hearty and satisfying main component for the casserole.
• Mayonnaise: Creamy ingredient that adds richness and helps bind the casserole mixture.
• Milk: Provides smooth texture and helps create a creamy consistency in the dish.
• Cream of Chicken Soup: Adds depth of flavor and creates a creamy sauce base.
• Cheddar Cheese: Sharp cheese that melts beautifully and adds a tangy, rich flavor.

• Onion: Adds subtle sweetness and depth of flavor to the casserole base.
• Roasted Red Peppers: Brings a sweet and slightly smoky flavor with a vibrant color.

• Biscuit Dough: Golden, fluffy topping that completes the casserole with a crispy exterior.
• Butter: Used for greasing the baking dish and sautéing onions, adds rich flavor.
• Non-Stick Spray: Alternative option for greasing the baking dish to prevent sticking.

How to Bake Creamed Chicken and Biscuits Easily

Step 1: Prepare the Oven

Preheat the oven to 350°F. Grease a baking dish with butter or non-stick spray.

Step 2: Sauté Onions

Melt 1 of butter in a skillet over medium heat. Add chopped onion and cook for 5 minutes until soft and translucent.

Step 3: Mix the Filling

• Sautéed onions
• Cooked chicken
• Cream of chicken soup
• Mayonnaise
• Milk
• Chopped roasted red peppers

Stir until all ingredients are well blended.

Step 4: First Baking Round

Spread the chicken mixture evenly in the prepared baking dish. Bake in the preheated oven for 15 minutes.

Step 5: Add Cheese and Biscuits

• Shredded cheddar cheese
• Biscuit dough
• Extra sprinkle of cheddar cheese

Step 6: Final Baking

• Biscuits turn golden brown
• Cheese melts completely

Step 7: Serve and Enjoy

Let the casserole cool for a few minutes. Serve with a side salad for extra freshness if desired.

Cozy Tips for Extra Fluffy Biscuits and Rich Gravy

• Choose Fresh Ingredients: Select high-quality, tender chicken and sharp cheddar cheese for maximum flavor depth.
• Perfectly Sauté Onions: Cook onions slowly and gently to develop a sweet, caramelized base that enhances the overall casserole taste.
• Control Moisture Balance: Don't overmix the chicken mixture to prevent a watery consistency; aim for a creamy, thick texture.
• Arrange Biscuits Strategically: Place biscuit dough pieces close together but not touching, allowing them to puff up and create a beautiful golden crust.
• Cheese Melting Trick: Sprinkle cheese in two stages – once before baking and again during the final minutes for a gorgeous, bubbling top layer.

How to Store and Reheat This Hearty Casserole Right

• Refrigerate Leftovers: Store the casserole in an airtight container within 2 hours of cooking. Cover tightly with plastic wrap or transfer to a sealed container to maintain freshness and prevent moisture loss. Refrigerated creamed chicken and biscuits will stay delicious for 3-4 days.
• Reheating Option 1 – Oven: Preheat the oven to 350°F and place leftovers in an oven-safe dish. Cover with aluminum foil to prevent drying out, then warm for 15-20 minutes until heated thoroughly. The foil helps retain moisture and keeps the biscuits from becoming too crispy.
• Microwave Reheating: For quick warming, place a single serving in a microwave-safe dish and heat in 30-second intervals. Stir between intervals to distribute heat evenly and prevent cold spots.

Sides That Go Well with Creamed Chicken & Biscuits

• Complement with Crisp Garden Salad: Toss together mixed greens, cherry tomatoes, cucumber slices, and a light vinaigrette to cut through the casserole's rich, creamy texture.
• Pour Chilled Chardonnay: Select a buttery, oak-aged Chardonnay with subtle apple notes that harmonize perfectly with the creamy chicken and complement the cheese's sharpness.
• Serve Tangy Coleslaw: Prepare a zesty coleslaw with shredded cabbage, carrots, and a light mayo dressing to provide a refreshing crunch that balances the casserole's warm, comforting flavors.
• Enjoy Sparkling Apple Cider: Opt for a cold, slightly sweet apple cider that refreshes the palate and adds a fruity contrast to the savory, cheesy dish.

Twist the Traditional with These Flavor Additions

• Herb-Infused Comfort: Replace roasted red peppers with fresh chopped herbs like thyme, rosemary, and parsley to create an aromatic and earthy flavor profile that enhances the creamy chicken base.
• Spicy Southwest Style: Add diced green chiles, jalapeños, and swap cheddar for pepper jack cheese to give the casserole a zesty, southwestern kick that brings warmth and excitement to the classic recipe.
• Mediterranean Makeover: Incorporate crumbled feta cheese, sundried tomatoes, and sprinkle oregano throughout the dish to transform the traditional casserole into a Mediterranean-inspired meal with tangy, bright notes.
• Protein Power Boost: Substitute chicken with shredded rotisserie chicken or add diced ham and turkey for a protein-packed version that provides extra heartiness and variety to the original recipe.

Creamed Chicken And Biscuits Casserole Recipe

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4.6 from 34 reviews

• Total Time: 50 minutes
• Yield: 6 1x

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Description

Southern comfort meets hearty hospitality in this Creamed Chicken and Biscuits Casserole. Savory chicken nestles beneath golden buttermilk biscuits, creating a comforting dish that brings family together around a warm, satisfying meal.

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Ingredients

Scale 1x2x3x

Main Protein:

• 2 pounds (907 grams) cooked chicken, cut or shredded
• 1 ½ cups (170 grams) mild cheddar cheese, shredded

Sauce and Liquid Ingredients:

• 1 can cream of chicken soup
• 1 cup (240 milliliters) milk
• ½ cup (120 milliliters) mayonnaise
• 1 tablespoon (14 grams) butter
• 1 small onion, chopped
• ½ cup (75 grams) roasted red pepper, chopped

Baking Components:

• 1 can refrigerated biscuit dough

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Instructions

1. Preheat the oven to 350°F (175°C) and generously grease a 9×13-inch (23×33 centimeters) baking dish with butter or non-stick cooking spray.
2. Melt 1½ tablespoons of unsalted butter in a medium skillet over medium heat, then sauté finely diced onions for 4-5 minutes until translucent and softened.
3. In a large mixing bowl, combine the caramelized onions with shredded cooked chicken, cream of chicken soup, creamy mayonnaise, whole milk, and diced roasted red peppers, stirring until all ingredients are thoroughly incorporated.
4. Pour the chicken mixture into the prepared baking dish, ensuring an even distribution across the surface.
5. Bake the initial layer for 15 minutes to develop the base flavors and create a bubbling foundation.
6. Remove the dish from the oven and generously sprinkle shredded sharp cheddar cheese over the chicken mixture.
7. Carefully arrange uncooked refrigerated biscuit dough on top of the cheesy layer, creating a rustic, overlapping pattern.
8. Scatter an additional handful of cheddar cheese over the biscuit dough for extra richness.
9. Return the casserole to the oven and bake for 18-22 minutes until the biscuits turn golden brown and the cheese melts completely.
10. Let the casserole rest for 5-7 minutes after removing from the oven to allow the layers to set and cool slightly.
11. Serve warm, optionally accompanied by a crisp green salad to balance the rich, creamy textures.

Notes

• Transform leftover roasted chicken into a comforting, creamy casserole that brings warmth to any dinner table.
• Roasted red peppers add unexpected sweetness and vibrant color to this classic comfort food dish.
• Mayonnaise creates an incredibly rich and smooth texture that elevates the entire casserole’s creaminess.
• Cheddar cheese provides a sharp, tangy flavor that perfectly complements the tender chicken and soft biscuits.
• Baking the entire dish allows flavors to meld together, creating a harmonious and satisfying one-pan meal that everyone will love.

• Prep Time: 15 minutes
• Cook Time: 35 minutes
• Category: Lunch, Dinner
• Method: Baking, Sautéing
• Cuisine: American

Nutrition

• Serving Size: 6
• Calories: 450 kcal
• Sugar: 2 g
• Sodium: 900 mg
• Fat: 25 g
• Saturated Fat: 10 g
• Unsaturated Fat: 12 g
• Trans Fat: 0.5 g
• Carbohydrates: 34 g
• Fiber: 1 g
• Protein: 24 g
• Cholesterol: 70 mg